U
Závěr: Naše zjištění prokázala, že UAOS-Na má jak myelin ochranné, tak protizánětlivé účinky. A mohl by snížit zánět RS snížením exprese Tapbp a H2-T23 v dráze prezentace antigenu MHC-I. cz
2022 Aug 17 Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran Ursolic Acid Enhances Myelin Repair in Adult Mice Brains and Stimulates Exhausted Oligodendrocyte Progenitors to Remyelinate
Kyselina ursolová zlepšuje opravu myelinu v mozcích dospělých myší a stimuluje vyčerpané progenitory oligodendrocytů k remyelinaci CZ
2022 Sep 2 Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei , Taiwan Ultrasound Neuromodulation Reduces Demyelination in a Rat Model of Multiple Sclerosis
Ultrazvuková neuromodulace snižuje demyelinizaci u potkaního modelu roztroušené sklerózy CZ
V
2022 Jun 10 Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran Immunomodulatory effects of cyclotides isolated from Viola odorata in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis
Imunomodulační účinky cyklotid izolovaných z Viola odorata v experimentálním zvířecím modelu CZ
2022 Aug Department of Rehabilitation Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China Effects of vibration training on motor and non-motor symptoms for patients with multiple sclerosis: A systematic review and meta-analysis
Účinky vibračního tréninku na motorické a nemotorické symptomy u pacientů s roztroušenou sklerózou CZ
May-Jun 2022 Feng Yang , Pey-Shan Wen Department of Kinesiology and Health (FY), Georgia State University, Atlanta, USA Effects of Vibration Training on Cognition and Quality of Life in Individuals With Multiple Sclerosis
Účinky vibračního tréninku na kognici a kvalitu života u jedinců s roztroušenou sklerózou CZ
2022 Oct Armed Forces Institute of Rehabilitation Medicine (AFIRM), Rawalpindi, Pakistan. The emerging role of focal muscle vibration in rehabilitation of neurological disorders
Vznikající role fokálních svalových vibrací v rehabilitaci neurologických poruch CZ
…nárůst svalové hmoty, lepší prokrvení, zlepšení hustoty kostí, snížení bolestí kloubů a zad.
2022 Jul 11 Department of Sport Science, University of Freiburg, Germany Six weeks of whole-body vibration improves fine motor accuracy, functional mobility and quality of life in people with multiple sclerosis
Šest týdnů celotělových vibrací zlepšuje přesnost jemné motoriky, funkční mobilitu a kvalitu života u lidí s roztroušenou sklerózou CZ
2022 Mar 2 Evelyne Wiskerke , Jan Kool Department of Rehabilitation Sciences, KU Leuven – University of Leuven, Leuven, Belgium Determining the Optimal Virtual Reality Exergame Approach for Balance Therapy in Persons With Neurological Disorders Using a Rasch Analysis: Longitudinal Observational Study
Určení optimálního cvičebního přístupu virtuální reality pro balanční terapii u osob s neurologickými poruchami pomocí Raschovy analýzy: longitudinální observační studie
2022 Oct 30 Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Spain Effectiveness of Virtual Reality on Balance and Risk of Falls in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis
Efektivita virtuální reality na rovnováhu a riziko pádů u lidí s roztroušenou sklerózou: Systematický přehled a metaanalýza CZ ..Léčba založená na VR je účinnější než neintervence při zlepšování rovnováhy a rizika pádu u lidí s RS
2022 Aug 3 Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Central vestibular dysfunction: don’t forget vestibular rehabilitation
Centrální vestibulární dysfunkce: nezapomínejte na vestibulární rehabilitaci CZ
2022 Aug 3 Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Central vestibular dysfunction: don’t forget vestibular rehabilitation
Centrální vestibulární dysfunkce: nezapomínejte na vestibulární rehabilitaci CZ
Asociace mezi znečištěním okolního ovzduší, obezitou a stavem vitaminu D v séru v obecné populaci dospělých Korejců CZ
W
2022 Sep 15 School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia Immediate effects of wearing textured versus smooth insoles on standing balance and spatiotemporal gait patterns when walking over even and uneven surfaces in people with multiple sclerosis
Okamžité účinky nošení texturovaných versus hladkých vložek na rovnováhu ve stoje a časoprostorové vzorce chůze při chůzi po rovných a nerovných površích u lidí s roztroušenou sklerózou CZ
2022 May Department of Biochemistry, Bharathiar University, Coimbatore, India Combination of Probiotics and Natural Compounds to Treat Multiple Sclerosis via Warburg Effect PMC
Kombinace probiotik a přírodních sloučenin k léčbě roztroušené sklerózy prostřednictvím Warburgova efektu CZ
Probiotics against MS:
| Lactobacillus, Bifidobacterium and Streptococcus | Clinical trial: MS subjects with glatiramer Acetate treatment – 7 Without treatment – 2 Healthy controls – 13 | Relapsing-remitting MS | Inhibits the infiltration of intermediated monocytes into the CNS | 72 |
| Lactobacillus paracasei and L. plantarum | Female Lewis rats 6–8-week age | Experimental auto immune myasthenia gravis | Reduces the CNS inflammation Inhibits Th1 and Th17 cytokines | 73 |
| Lactobacillus reuteri | Female mice wild-type (WT) C57BL/6 (10 weeks-age) | EAE | Reduced TH1/TH17 cells and their associated cytokines IFN-g/IL-17 | 74 |
| Lactobacillus plantarum and Bifidobacterium animalis | Female C57BL/6 mice (8–10 weeks age) | EAE | Improved the state of CD4+CD25+Foxp3+-expressing T-cells in the spleen and the lymph nodes | 75 |
| Saccharomyces boulardii | Double-blind randomized controlled two-group parallel Clinical trial of 50 MS patients | MS | Reduces CNS inflammation, fatigue, pain and oxidative stress | 24 |
| Lactobacillus acidophilus, lactobacillus casei, Bifidobacterium bifidum and Lactobacillus fermentum | Randomized, double-blind, placebo-controlled clinical trial of 40 MS patients | MS | Down regulates the gene expressions of IL-8 and TNF-α | 76 |
| Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus reuteri, Bifidobacterium bifidum and Streptococcus thermophilus | C57BL/6 mice (6–8 weeks-age) | EAE | MOG-reactive T cell propagation and pro-inflammatory cytokine levels are reduced and improving IL10+ or/and Foxp3+ Treg cells. Inhibits the pro-inflammatory Th1/Th17 polarization. | 77 |
| Lactobacillus plantarum and Bifidobacterium B94 | 32 male Wistar rats | Ethidium bromide induced demyelination | Improves the spatial memory and learning. | 78 |
| Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum and Lactobacillus fermentum | Randomized, double-blind, placebo-controlled clinical trial of 60 MS patients | MS | Shows improvements in expanded disability status scale, mental health and HDL- cholesterol levels. | 79 |
| Bifidobacterium infantis, Bifidobacterium lactis, Lactobacillus reuteri, Lactobacillus casei, Lactobacillus plantarum and Lactobacillus fermentum | Randomized, double-blind, placebo-controlled clinical trial of 48 MS patients | MS | Decreases the levels of hsCRP and IL-6 and increased the anti-inflammatory cytokine IL-10 | 80 |
| Streptococcus thermophilus | Female SJL/J mice, (6–9 weeks age) | MBP83–99 peptide immunized MS model | Inhibited the secretion of pro-inflammatory cytokines IL-1β and IFN-γ and enhances the secretion of anti-inflammatory cytokines IL-4, IL-5, IL-10 |
Effect of natural compounds in MS:
| Bio-active components | Study design | Type of MS/study models | Effect of bioactive component in MS | Ref. |
| Curcumin | Adult female Lewis rats (150-200 g) | Experimental autoimmune encephalomyelitis (EAE) (animal model of MS) | Reduces the oxidative stress Enhances remyelination process | 55 |
| Cannabis | Randomized placebo-controlled, double-blind parallel group study of 160 MS patients | MS | Effective for spasticity associated with MS | 56 |
| Epigallocatechin-3-gallate | Randomized, double-blind, placebo-controlled, crossover trial of 18 MS patients | Relapsing-remitting MS | Improves muscular metabolism to a greater extent in men than in women | 57 |
| Crocus sativus L. | 8-week-old C57BL/6 mice | EAE | Inhibits oxidative stress and prohibits leukocyte infiltration to CNS | 58 |
| Ginger | Female 6- to-8-week age C57BL/6 mice | EAE | Reduces the infiltration of inflammatory cells into the CNS | 59 |
| Andrographis paniculata | Randomized double-blind placebo-controlled trial of 25 patients | Relapsing-remitting MS | Reduces the chronic fatigue | 60 |
| Dendropanaxmorbiferus | 13.5 days pregnant females mice or pups | Oligodendrocytes (OLs) primary culture systems | Enhances oligodendrocytes development | 61 |
| Terminalia ferdinandiana | Antibacterial activity against the strains of A. baylyi and P. aeruginosa | Bacterial triggers of MS | Inhibits the growth of Acinetobacter baylyi and Pseudomonas aeruginosa which triggers MS | 62 |
| Boswellia papyrifera | Clinical trial of 80 MS patients | Relapsing remitting MS | Improves the visual and spatial memory. | 63 |
| Scrophulariamegalantha | Nineteen C57BL/6 female mice- weighing 18-20g (7-to 9 week-age) | EAE | Down-regulates the production of IFN-γ and IL-17 and up-regulates the anti-inflammatory IL-10 | 64 |
| Saffron | Adult male Wistar rats (200-250 g) | Ethidium bromide induced demyelination | Improves spatial learning memory and antioxidant enzyme activity | 65 |
| Resveratrol | Male C57Bl/6 mice (20-25 g) | Cuprizone induced demyelination | Improves mitochondrial function, remyelination, motor coordination reduces oxidative stress by enhances the expression of Olig1 gene and inhibited NF-κB signaling pathway | 66 |
| Resveratrol | Female SJL/J mice (6-week age) | EAE | Exhibits neuro-protective activity by the activation of SIRT1 mechanism | 67 |
| Cannabis | Randomized clinical trial of 144 MS patients | MS | Improves pain relief and muscle stiffness in MS patients | 68 |
| Curcumin | Rat embryonic hippocampal neuron- from 17-days pups | Primary hippocampal neuron cell culture study | Protects axon degradation by inhibiting microglial MyD88/p38 MAPK signaling and nitric oxide production |
2023 Feb State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, China Effectiveness evaluation of water-sprinkling in controlling urban fugitive road dust based on TRAKER method
Hodnocení účinnosti kropení vodou při kontrole městského fugitivního silničního prachu na základě metody TRAKER CZ
2022 Nov 12 The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, China Wuzi Yanzong Pill Plays A Neuroprotective Role in Parkinson’s Disease Mice via Regulating Unfolded Protein Response Mediated by Endoplasmic Reticulum Stress
Pilulka Wuzi Yanzong hraje neuroprotektivní roli u myší s Parkinsonovou nemocí prostřednictvím regulace rozvinuté proteinové odezvy zprostředkované stresem endoplazmatického retikula CZ ….zlepšila motorické symptomy a patologické léze u PD myší,
Wuzi Yanzong Pill relieves CPZ-induced demyelination by improving the microenvironment in the brain
Wuzi Yanzong Pill zmírňuje demyelinizaci vyvolanou CPZ zlepšením mikroprostředí v mozku CZ …Závěr: Naše výsledky ukázaly, že WYP podpořila proliferaci a vývoj oligodendrocytů zlepšením mikroprostředí CNS a účinně zmírnila demyelinizaci
Wuzi Yanzong Pill zmírňuje motorickou dysfunkci vyvolanou MPTP a ztrátu neuronů tím, že inhibuje neurozánět zprostředkovaný zánětem NLRP3
2023 Aug Wuzi Yanzong Pill protects neural tube defects by activating PI3K/Akt signaling pathway
Wuzi Yanzong Pill chrání defekty neurální trubice aktivací signální dráhy PI3K/Akt cz
2023 Sep 21
The Molecular Basis of Wnt/ β-Catenin Signaling Pathways in Neurodegenerative Diseases
Molekulární podstata Wnt/ β -Cateninových signálních drah u neurodegenerativních onemocnění CZ
2023 Aug 18 Dietary wheat amylase trypsin inhibitors exacerbate CNS inflammation in experimental multiple sclerosis
Dietní inhibitory pšeničné amylázy trypsinu zhoršují zánět CNS u experimentální roztroušené sklerózy cz
Útlum imunitní aktivace u pacientů s roztroušenou sklerózou na dietě se sníženým obsahem pšenice: pilotní křížová studie cz
Nejnovější komentáře